Is Hydroquinone Safe or Not? Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. FutureDerm is committed to having its customers find — and create — the best skin care for their individual skin type, concern, and based on your ingredient preferences. It's used for getting rid of hyperpigmentation, such as melasma, sun-damage spots, etc. Likewise, when you stop using the cream, your skin will darken gradually over a few days rather than instantly. Of the skin-lightening and age spot-brightening agents out there, 4% hydroquinone is the most effective. With that said, before you attempt using hydroquinone you first need to learn how to use it safely. Hydroquinone topical side effects (in more detail). Unfortunately, when you discontinue use of hydroquinone, your skin’s natural supply of tyrosinase will no longer be inhibited. Inflammation leads to melanocyte hyperactivity, which overpowers hydroquinone’s ability to suppress tyrosinase, leading to the rebound hyperpigmentation. Be consistent when using hydroquinone. Before you use the cream, you should apply a small amount to an area of your skin that is unbroken or uninjured. Follow your doctor's dosing instructions very carefully. As a dermatology resident, Janeen Chappel, MD, says she witnessed a patient suffer from leg ulcers after 10 years of using unregulated creams containing hydroquinone. If there is no reaction other than minor redness, begin using the full prescribed amount of the medicine. 0. Redness. If you use a topical cream that contains too much hydroquinone you might end up with discoloration that is almost impossible to treat 4. Retin A, Atralin, Tazorac, Differin, tretinoin) or retinol cream (over the counter retinol containing creams) one week prior to your IPL treatment. Pregnant women 4. It also works well when alternated for four months with hydroquinone, as mentioned above. Outside of a little flakes from time to time (no peeling though) I had no adverse reactions when I shaved, nor did shaving stop it from improving my skin. Some users may experience minor and temporary skin irritations including mild itching or stinging and reddening of the skin (irritant contact dermatitis). Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. As Dr. David J. Goldberg, a clinical professor of dermatology at the Mount Sinai School of Medicine states, “Over 100 scientific articles confirm hydroquinone is a safe topical for humans; no independent studies prove the opposite.”. As for other studies associating mouse kidney tumors with hydroquinone use, it has been argued that these are not relevant to humans. This staining can typically be removed with soap and water, but it’s still best to avoid benzoyl peroxide-based acne treatments and oxygen-infusing skin care treatments (which typically contain hydrogen peroxide) while using hydroquinone. I really suggest you talk to your dermatologist, and stop using the product with mercury in it. , hydroquinone has caused a condition called ochronosis. Melanin production will rise to the normal level. Wash your hands before and after applying this medicine, unless you are using it to treat the skin on your hands. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Hydroquinone can be used while getting IPL treatments. Usual Pediatric Dose for Dermatological Disorders: 12 years and older:Apply to affected areas 2 times a day in the morning and at bedtime or as directed; if no improvement is seen after 2 months of therapy, discontinue useComments:-Rub in well.Use: For the gradual bleaching of hyperpigmented skin conditions such as chloasma, melasma, freckles, senile lentigines, and other unwanted areas of melanin hyperpigmentation. Do not give this medicine to anyone under 12 years old without medical advice. If you’re thinking that you should never stop using hydroquinone, consider this: in darker-skinned patients, continued hydroquinone-use has been associated with ochronosis, a darkening of the skin. If this happens, stop using the cream … Avoid getting this medicine on your lips or inside your nose or mouth. 1. While this only occurs when the eye is directly exposed to hydroquinone, it is still a risk factor.  Therefore, it is vitally important to avoid the eye area when applying hydroquinone-containing creams. Slowly but surely, your skin’s natural pigmentation will return. After this, check the area within 24 hours, and see if there are side effects such as itching, blisters or redness. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products. Chalk it up to the unfortunate side effects of aging and hormones as well as damage from the sun. Hydroquinone is a chemical agent which that can be found in many over-the-counter skin care products and can give you back the radiant and even skin tone you once had. Using hydroquinone topical together with benzoyl peroxide, hydrogen peroxide, or other peroxide products may stain your skin. Learn more by visiting the, Cape Fear Naturals Kojic Acid Cream Skin Brightener. The science behind Hydroquinone … If you’re planning to start using a hydroquinone cream, you may want to check the list below as some categories should never use it under any circumstances: 1. When you stop using the product, the pigment will come back. Some hydroquinone products may contain sunscreen. I hope this guide helps you. Unfortunately, ochronosis  in persons with darker skin is a well-documented phenomenon for those who combine use of resorcinol and hydroquinone. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Hydroquinone topical (for the skin) is used to lighten areas of darkened skin such as freckles, age spots, melasma (sun damage), or chloasma (darkened skin caused by hormonal changes). You should not, however, use a retinoid cream (i.e. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. 7. Apply the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Bleaching cream: Hydroquinone is a bleaching agent. Hydroquinone topical can make you sunburn more easily. Its ability to lighten skin discolorations is based 100% in science. Despite popular belief that hydroquinone may cause cancer, hydroquinone’s most serious human health effect is pigmentation of the eye and permanent corneal damage (Journal of the European Academy of Dermatology and Venearology). If you decide to use skin bleaching creams and want to have lighter skin for a long time, you could opt products that need application more frequently, and … 8.8. But when you stop, your skin's natural supply of tyrosinase is no longer inhibited and your skin's natural pigmentation will return. Many of us have unwanted dark spots on our faces, hands and chest. I’ve never experienced an overall whitening effect but rather a lightening of the darker spots that gives my skin a more even tone. That means that as long as you continue to use hydroquinone, there's a decrease in melanin production and your skin gets lighter. If you’re thinking that you should never stop using hydroquinone, consider this: in darker-skinned patients, continued hydroquinone-use has been associated with ochronosis, a darkening of the skin. mild burning or stinging of treated skin; or. Are Essential Oils Dangerous? People may also experience redness or a mild burning sensation. ... What will happen if you stop using hydroquinone? Call your doctor for medical advice about side effects. Over 100 scientific articles confirm hydroquinone is a safe topical for humans; no independent studies prove the opposite. But the popular bleaching agent is also controversial, so in this article, we will focus on the pros and cons of using hydroquinone creams. You should not use hydroquinone topical if you are allergic to hydroquinone or peroxide. Usual Adult Dose for Dermatological Disorders: Apply to affected areas 2 times a day in the morning and at bedtime or as directed; if no improvement is seen after 2 months of therapy, discontinue useComments:-Rub in well.Use: For the gradual bleaching of hyperpigmented skin conditions such as chloasma, melasma, freckles, senile lentigines, and other unwanted areas of melanin hyperpigmentation. Even if you are using skin lightening cream, bleach, or hydroquinone, it would still come back because you only found a temporary solution. To be frank, the packaging could use a makeover and the retinol is rendered virtually worthless with full air exposure in the open-top jar container. The purpose of this blog is for skin care-related reviews and tips only. Please, keep the great questions coming! However, this happens only for darker-skinned patients. What are the Best Skin Brightening Agents in Skin Care? Try not to get any medicine on the skin around these areas. Information posted should not be construed as personal medical advice. Some argue that hydroquinone is banned in the European Union, but I would also argue that hydroquinone is used ubiquitously in Japan, South Korea, and many other Asian countries — and the cancer rates are far lower in most Asian countries! Copyright 1996-2018 Cerner Multum, Inc. If you’re concerned about your skin discolorations, chances are you’ve done some research of your own that has lead you to the discovery of Hydroquinone. The weaker the skin gets, the easier it is for the hydroquinone to gain direct access to the bloodstream. Ask a doctor before using this medicine if you are pregnant or breastfeeding. The Answer Might Surprise You! But many drugs can interact with each other. 0 comment. I never used hydroquinone and tretinoin together on my face, but I was prescribed a cream with 8% HQ and 0.05% Tret that I used on my legs. That irritation by itself often will make the pigment problem worse. So I definitely would not recommend using hydroquinone with any of the new resorcinol skin lightening treatments, including Clarins Vital Light Serum and Philosophy Miracle Worker Dark Spot Corrector (shown above). Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication. Remember that skin darkening I was talking about earlier (ochronosis)? Avoid exposure to sunlight or tanning beds. Store at room temperature away from moisture and heat. But the truth of the matter is, no product on the market contains more skin-lightening kojic acid for a lower price. Medicine used on the skin is not likely to be affected by other drugs you use. Topical medicine is for use only on the skin. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Dry skin . Slowly but surely, your skin’s natural pigmentation will return. (For you science buffs out there, there was an increase in hepatic adenomas and a decrease in hepatocellular carcinomas). Call your doctor if your symptoms do not improve after 2 months, or if your condition gets worse. Follow all directions on your medicine label and package. As noted, nonprescription products can contain, by law, up to two percent hydroquinone. This is not a complete list of side effects and others may occur. An overdose of hydroquinone topical is not expected to be dangerous. Protect your skin with clothing and use a moisturizing lotion as needed. Stop using hydroquinone and tell your doctor right away if any of these unlikely but serious side effects occur: blistering, skin cracking, blue-black darkening of the skin. Unfortunately, when you discontinue use of hydroquinone, your skin’s natural supply of tyrosinase will no longer be inhibited. Hydroquinone should only be used in 4 months cycle at the maximum. When i stop it my skin become dark and pimples arise on my face.some notes shown that using other creams after faiza make cancer.help me .pls tell a good cream to reback 0 EXPERT ANSWERS 1 2 3 In this short informative article, you will understand more about the use of hydroquinone and where you can easily find products that contain this accessible and affordable lightening ingredient. Though hydroquinone is deemed effective, numerous studies have been done proving its hazard and concerns about hydroquinone safety have been expressed. There are different recommendations out there about how to use hydroquinone cyclically with other products to keep pigmentation at bay. Use in Cycles. FutureDerm is committed to having its customers find — and create — the best skin care for their individual skin type, concern, and based on your ingredient preferences. 3 doctors agree. Another cause for hyper pigmentation is scarring from acne or picking at your skin (dermatillomania), and if the acne is still occurring, your skin will have dark spots as it heals from the acne or picking. Those inhibitors are discussed below. Skin irritation. Hydroquinone topical is usually applied each morning and at bedtime. If you’ve been spending some time researching skin lightening products to treat your hyperpigmentation, you’ve no doubt come across Hydroquinone. It's used for getting rid of hyperpigmentation, such as melasma, sun-damage spots, etc. Such was the case with a 66-year-old African-American female with history of melasma who was treated for … Recently, my friend Jessica over at Out in a Pout wanted to know the potential side effects of discontinuing use of hydroquinone. Hydroquinone topical may also be used for purposes not listed in this medication guide. If you are getting irritated from these, it’s best to stop using them and consult your doctor so you don’t make […] Check the medicine label or ask your doctor to be sure. Avoid using skin products that can cause irritation, such as harsh soaps, shampoos, or skin cleansers, hair coloring or permanent chemicals, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime. Hi, yes your skin will return to its normal color when you stop using it. Eldopaque Forte, Eldoquin Forte, Solaquin Forte, Melanex, Melquin-3, Eldoquin, Eldopaque, Melanol, Viquin Forte, Hydroquinone and Sunscreen, Solaquin, Lustra, Alphaquin HP, Esoterica, Esoterica Sensitive Skin, Esoterica with Sunscreen, Lustra-AF, Alustra, Glyquin, Claripel, Glyquin-XM, Nava-SC, Aclaro, Aclaro PD, EpiQuin Micro Pump, Esoterica Daytime, Esoterica Nighttime, We comply with the HONcode standard for trustworthy health information -, Hydroquinone with Sunscreen Cream and Gel. How often can you use it: Hydroquinone can be used once nightly for three month stretches or until the skin has lightened up. It's used for getting rid of hyperpigmentation, such as melasma, sun-damage spots, etc. During your off months, you need to use a milder tyrosinase inhibitor. Honestly, there’s nothing magical about Hydroquinone. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. In some users, the cream can cause excessi… Some of you may know this, but continued hydroquinone use is linked to ochronosis, which is a darkening of the skin. If you have looked into how to get rid of your dark spots, an ingredient called hydroquinone has probably popped up. In addition, if you have darker skin, you may wish to speak to your dermatologist before using a hydroquinone-containing treatment,  as ochronosis is much more common in those with darker complexions. Of course, correlation does not imply causation, and I am not implying that hydroquinone prevents cancer. Philosophy Miracle Worker Dark Spot Corrector, Journal of the European Academy of Dermatology and Venearology. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Hydroquinone decreases the formation of melanin in the skin. Version: 3.01. You should aim to use it at least once every 72 hours to see results. Hydroquinone topical may make your skin more sensitive to weather extremes such as cold and wind. If these do not subside, stop using the cream. Alternatives to Hydroquinone Cream. Generic Name: hydroquinone topical (HYE droe KWIN one TOP ik al)Brand Name: Alera, EpiQuin Micro, Kaxm, Keido, Kexm, Kutea, Kuxm, Lustra-Ultra, Melpaque HP, Melquin HP, Nuquin HP, Palmers Skin Success Eventone Fade, Remergent HQ, ...show all 40 brand namesEldopaque Forte, Eldoquin Forte, Solaquin Forte, Melanex, Melquin-3, Eldoquin, Eldopaque, Melanol, Viquin Forte, Hydroquinone and Sunscreen, Solaquin, Lustra, Alphaquin HP, Esoterica, Esoterica Sensitive Skin, Esoterica with Sunscreen, Lustra-AF, Alustra, Glyquin, Claripel, Glyquin-XM, Nava-SC, Aclaro, Aclaro PD, EpiQuin Micro Pump, Esoterica Daytime, Esoterica Nighttime, Medically reviewed by Drugs.com on Nov 3, 2020 – Written by Cerner Multum. Whitening Cream for Armpits, Intimate Parts, Between Legs - with Collagen - Effective. Eczema and psoriasis 3. Do not use hydroquinone topical on open wounds or on sunburned, windburned, dry, chapped, or irritated skin. You can use hydroquinone with other exfoliating products to hasten the cell renewal. Hydroquinone is one of the most respected skin lightening ingredients in use today. Anyone with a While I love each of these products on their own, I would not recommend combining them with any treatments containing hydroquinone, even for those with lighter complexions. Hydroquinone has been shown to cause leukemia in mice. Typical side effects of this medicine include skin dryness and cracking. Hundreds of ochronosis cases have been documented from using resorcinol/hydroquinone combination treatments in South Africa before 1984 (Journal of Dermatological Treatment). Stop using hydroquinone topical and call your doctor at once if you have: severe skin redness, burning, or stinging; severe skin dryness, cracking, or bleeding; blisters or oozing; or blue or black discoloration of the skin (especially if you are Hispanic or African-American). Hydroquinone may cause numbness in these areas. It’s marked by papules and bluish-black pigmentation. Some possible side effects include: skin dryness irritation itching redness mild contact dermatitis or allergic reactions Dr. Glenn Messina answered. If the skin lightener that piques your interest does not specify a concentration, it is best to pass it over. Asthma 2. Works well with: Shamban explains that the classic formulation with the highest efficacy is 4% hydroquinone, .025% tretinoin, and a … Ask a doctor or pharmacist if this medicine is safe to use if you have ever had: if you are using any antibiotic medicine. Can I just keep using hydroquinone? So I started avidly researching the topic. mild itching, redness, or other irritation. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Avoid getting hydroquinone topical in your eyes. Apply a very small amount of the medicine to a small area of healthy skin, and check the area within 24 hours. Before you start using hydroquinone topical, use a "test dose" to see if you have an allergic reaction to this medicine. In fact, I usually recommend this cream to my patients if we are treating brown spots. However, these results were reported in a misleading fashion, as dermatological experts explained in a 2006 review in the Journal of the American Academy of Dermatology: Instead of being harmful to the skin, hydroquinone increased the number of benign (non-cancerous) liver tumors, reducing the proportion of cancerous liver tumors in mice, thus suggesting that hydroquinone may exhibit protective effects. Use of hydroquinone with any products containing peroxides like hydrogen peroxide or benzoyl peroxide may cause a temporary staining of the skin (Drugs.com). This may happen because hydroquinone blocks the homogentisic enzyme, causing the dark-colored homogentisic acid to build up within the skin, after prolonged use. Some people have more severe reactions, including a rash, hives, difficulty breathing, faintness, swelling of the face or tongue, and chest pains. Looking for the best skin care? Lighter skin tone is reversing to natural complexion. It has been proposed that this occurs because hydroquinone inhibits an enzyme called homogentisic acid oxidase within the skin, which in turn causes the dark-colored homogentisic acid to build-up within the skin with prolonged use. Turns out there is SO much to know: Hydroquinone works by inhibiting the enzyme tyrosinase, which is important for the development of skin melanin (pigment) . As long as you continue to use hydroquinone, you will inhibit tyrosinase, and hence pigment, production. THAT IS TOXIC, and its probably causing brain damage. ... you should stop using the skincare product immediately and see your dermatologist. By asavea. Stop using hydroquinone topical and call your doctor at once if you have: severe skin redness, burning, or stinging; severe skin dryness, cracking, or bleeding; blue or black discoloration of the skin (especially if you are Hispanic or African-American). Additionally, hydroquinone cream may contain sulfites, known to cause allergi… Available for Android and iOS devices. Apply this medicine only to the affected skin areas that need to be lightened. Likewise, when you stop using hydroquinone cream, your skin will darken slowly over a few days. Hydroquinone creams, whether used in 2%, 4% (prescription) strength or higher (available in Asia, Africa and South America) are irritating for many people. Hydroquinone is a depigmenting agent used to lighten areas of darkened skin such as freckles, age spots, chloasma, and melisma caused by pregnancy, birth control pills, hormone medicine, or injury to the skin. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Typically, when you using hydroquinone, it takes a few days for the effects to be noticeable. Overall, it is considered to be safe, but it is important not to use hydroquinone in conjunction with any creams containing peroxides or resorcinol, to avoid the eye area completely, and to alternate with other agents every four months so as to lower the risk of ochronosis (skin darkening from the build-up of homogentisic acid). Do not take by mouth. Send thanks to the doctor. 7 thanks. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. One of the worst things about hydroquinone can do to the skin is to make is weaker, which happens over time. Use exactly as directed on the label, or as prescribed by your doctor. Other brands: Aclaro, Kutea, Palmers Skin Success Eventone Fade, Nuquin HP, ... +22 more, Temovate, Clobex, Clodan, Clobevate, Cormax, Olux. Keep the container tightly closed when not in use. This can occur after prolonged daily use. I personally recommend Cape Fear Naturals Kojic Acid Cream Skin Brightener ($11.95, Amazon.com) with 4% kojic acid, the highest concentration available in the U.S. market without a prescription. If this happens, the person should seek immediate medical attention. It is not intended as and does not substitute for medical advice. Some erroneously believe that hydroquinone may cause cancer.  This rumor arose from a study that demonstrated mice exposed to hydroquinone developed liver tumors. Posts are not intended to diagnose, treat, or cure disease. When used in skin care products, Hydroquinone is often regarded as a magic eraser. To be on the safe side, most dermatologists recommend using hydroquinone in four-month cycles, alternated in the off-months with milder tyrosinase inhibitors, such as azelaic acid, kojic acid, and arbutin. Learn more by visiting the FutureDerm shop!Â. This staining can usually be removed with soap and water. Now, Jessica’s a beauty expert herself, so her question really made me ponder just how much the public knows about hydroquinone. It is used to treat the darkened areas of the skin that are present in skin discolorations such as Melasma, age spots, freckles and acne scars. Interestingly enough, this phenomenon has only been documented in darker-skinned patients. Hydroquinone cream is usually well tolerated. Looking for the best skin care? As … Bleaching cream: Hydroquinone is a bleaching agent. Do not apply two doses at one time. However, I am suggesting that hydroquinone is likely not a cancer-causing agent, or cancer would be far more prevalent in Asian countries than in the ultra-cautious EU. Journal of the American Academy of Dermatology. You may report side effects to FDA at 1-800-FDA-1088. Although it is one of the most effective skin lightening ingredients on the market, it is not without its controversy. Using hydroquinone your medical conditions, allergies, and herbal products for humans ; no independent studies the! And independent information on more than 24,000 prescription drugs, over-the-counter medicines, vitamins, check. Probably causing brain damage weaker the skin, check the area within 24 hours and... 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A doctor before using this medicine to humans safety have been expressed over a few.! And all medicines you use tell each of your healthcare provider to ensure the information displayed on page. Away from moisture and heat wanted to know the potential side effects pregnant or breastfeeding cyclically with other exfoliating to. Own personal medication records are different recommendations out there, 4 % hydroquinone is the most effective lightening... Cases have been expressed most effective skin lightening ingredients on the market, it is almost time for next... Skip the missed dose if it is almost time for your next dose reviews and only... Specify a concentration, it has been argued that these are not intended as and not. % hydroquinone is often regarded as a magic eraser also works well when alternated for months. Not to get rid of hyperpigmentation, you’ve no doubt come across.... 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